At the soonest in the stomach.
I usually hold a cap in my mouth until it at least softens and usually until I can at least feel some of the herb starting to come out.
Why?
The guy that pumped our septic tank told us that he always finds UNDISSOLVED capsules in septic systems. What a waste of money for those folks.
I can tell you that our capsules do start dissolving very quickly. Just a very small amount of moisture on our machine causes them to start and then stick in the contraption.