Hi David, I know Japanese Knotweed has been discussed in the forum so you might find more information on that thread but what I had shared was that it is an “invasive weed” where the root is the medicine (so God made it prolific on purpose;). Where the root is the medicine, it is usually best to wait a couple years before harvesting to get good medicinal value. Japanese Knotweed is high in Resveratrol which makes it useful with Lyme protocol (Buhner) and a cytokine inhibitor (Doc Jones shared in the Forum that it is a good alternative to Grape Leaf for this purpose, see Cytokine Balance formula). I have used it in supplemental form following the Lyme protocol … and there is lots of clinical studies on the value of Resveratrol. I hope you found this helpful 🙂