I have used prickly lettuce on my elderly dog who had tremors in her back legs from arthritis pain. (She had since passed away) It helped lessen the tremors. The white latex inside the stem is what you want. I cut the main stem lengthwise to expose it, then boiled for twenty minutes. I put one quarter cup of the tea on her food twice a day. She weighed 50 lbs.
I think you could make a tincture with everclear. I don’t see why not? I’m guessing one teadpoon, pretty much like everything else.